Accelerate hit discovery with Affinity Selection–Mass Spectrometry
Analytical Studio automatically screens compound libraries against biological targets, identifies non-covalent binders using isotopic pattern matching, and delivers validated hit lists — at the scale modern drug discovery demands.
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AS-MS data is too complex for manual review
Affinity Selection-Mass Spectrometry can screen thousands of compounds per well. The resulting data — spanning chromatograms, mass spectra, isotopic patterns, and metadata — makes manual analysis a bottleneck. False positives accumulate. Hit rates go uncalculated. Binding affinity data arrives too late to inform compound selection.
Analytical Studio was purpose-built to solve this: managing data volumes, applying multi-layer filters to confirm compound presence, and reducing both false negatives and false positives — automatically, at scale.
One platform for the entire AS-MS workflow
Automated Hit Identification
Analyze multiplexed samples containing thousands of compounds per well. Isotopic pattern matching automatically identifies potential binders — without manual spectral review.
Confidence in Every Result
Cross-hit filtering automatically checks masses across samples to identify background peaks — replacing the hours of manual review that previously stood between a run and a reliable hit list.
Binding Affinity, Earlier
Integrated Kd calculations and dose-response curve analysis deliver critical kinetic parameters within the AS-MS environment — enabling better compound ranking before downstream investment.
All the data, in one place
The Analytical Studio interface simultaneously displays chromatograms, mass spectra, and processed results in a single integrated view. Access ppm errors, retention times, isotopic pattern matching scores, and compound metadata without switching between tools or windows.
- Chromatograms, spectra, and results displayed together
- ppm errors, retention times, and isotopic scores in context
- Customizable layout to match your review workflow
- Compound metadata alongside spectral data
Reduce false positives with cross-hit filtering
An advanced automated process cross-checks masses in other samples within a run to identify background peaks — flagging them before they reach your hit list. What once required hours of manual review now happens automatically, at scale.
- Automatically cross-checks masses across all samples
- Confirmed cross-hits flagged separately from confirmed hits
- Eliminates hours of manual background peak review
- Reduces false positives without introducing false negatives
Go from compound list to validated hit list with ease
Analytical Studio supports comprehensive hit validation using multiple injection types — references, bound samples, unbound samples, competitor compounds, and blanks — automatically associated together for each compound. Integrated sample management and sample list building complete the end-to-end pipeline.
- Supports references, bound, unbound, competitor, and blank injections
- Injection types automatically paired with their corresponding hits
- Fully integrated with AS-SMS and AS-SLB for pipeline automation
- Reduce decision risk before committing to costly follow-up assays
Kd and dose-response curve analysis
An optional add-on module integrates Kd calculations and dose-response curve (DRC) analysis directly into the AS-MS workflow. Acquire binding affinity data at the screening stage — earlier than any downstream assay could provide it — and use it to rank compounds and prioritize candidates with greater confidence.
- Kd calculations within the AS-MS environment
- Dose-response curve analysis for hit ranking
- Earlier access to kinetic parameters improves candidate selection
- Reduces the cost of advancing weak binders into follow-on work
Expression-driven logic and customizable methods
The Analytical Studio interface simultaneously displays chromatograms, mass spectra, and processed results in a single integrated view. Access ppm errors, retention times, isotopic pattern matching scores, and compound metadata without switching between tools or windows.
- Chromatograms, spectra, and results displayed together
- ppm errors, retention times, and isotopic scores in context
- Customizable layout to match your review workflow
- Compound metadata alongside spectral data
See Analytical Studio in your screening workflow
Whether you're running primary screens, validating hits, or adding Kd analysis to your pipeline — talk to an expert about how Analytical Studio fits your specific workflow.
- Screen compound libraries of thousands of compounds per well
- Automate hit identification, filtering, and validation end-to-end
- Access binding affinity data earlier in your discovery campaign
- Trusted by 80% of the top 10 global pharmaceutical companies