Publications
A Quantitative Assessment Of Large Scale Data Processing For LC/UV And MS Based Compound QC
Pittcon 2010, Orlando, FL, USA, 23rd – 27th Januray 2010, Mark Bayliss, Joseph Simpkins
In our experience, we have found a significant number of situations that force us to have to QC a much greater percentage of our LC/MS UV, ELSD compound QC results than we feel should be really necessary. This oftentimes means a 100% QC. Some […]
Elimination Of The LC/MS Data Analysis Workflow Bottlenecks In Substance QC
Laboratory Automation (ALA 2010), Palm Springs, CA, USA, 1st – 4th March 2010, Mark Bayliss, Joseph Simpkins
Previously, within our research and services as a Clinical Research Organization we were constantly challenged with how to accurately and reliably determine the presence or absence of target substances within minimal analyst intervention. Most of these types of studies were in […]
Enabling High Throughput MRM Based Biomarker Validation Studies Through A Vendor Neutral Application
Joseph Simpkins
A modern current trend in biomarker validation is to profile well known systems using specific higher sensitivity assays based on quantitative mass spectrometry MRM experiments. Chemical biomarkers evaluated using these tools range from multiple peptide targets in plasma to panels of small molecules (e.g. biogenic amines) in cerebral spinal fluid. In all […]
Elimination Of The LC/MS Data Analysis Worklfow Bottleneck Using Analytical Studio
Joseph Simpkins
Modern mass spectrometry labs usually contain instruments from multiple vendors generating data for hundreds to thousands of samples per day. The challenge facing most labs today is not data generation. Rather, it is data interpretation.How do labs keep from being buried under all of the data they can generate? We have implemented a software […]
An Interview With Kenneth Lewis Opans And Joseph Simpkins Virscidian
Joseph Simpkins, Kenneth Lewis
An interview with Kenneth and Joseph on running a CRO, the challenges and how Opans differentiates itself from other similar companies. Factors affecting the collection, storage and analysis of QC data…
Joseph Simpkins states:
“We have all of the raw data, all of the processed data, all of the results, all of the meta […]