Automated Kd Analysis in Affinity Selection-Mass Spectrometry

Analytical Studio now auto calculates Kd from AS MS dose response data, providing interactive plots, exportable results, and built in fit statistics.

Automated Kd Analysis in Affinity Selection-Mass Spectrometry

Analytical Studio now auto calculates Kd from AS MS dose response data, providing interactive plots, exportable results, and built in fit statistics.

Automated Kd Analysis in Affinity Selection-Mass Spectrometry

The latest add on to Analytical Studio Professional extends its Affinity Selection-Mass Spectrometry workflow with fully automated dose response analysis and Kd determination.  Simply open a data set that contains serial ligand concentrations: the software extracts peak areas and intensities, fits the binding model, and returns Kd, Bmax, and R² values in seconds, no spreadsheet gymnastics required.

A flexible dashboard keeps every layer of evidence in view at once: well plate heat map, EIC, mass spectrum, substance metadata, and live linked dose response curves.  Click any point on the plot and the corresponding chromatogram and spectrum update instantly, making outliers easy to spot.

Quality of fit metrics go beyond the curve itself.  Linear fit statistics and peak area vs. peak intensity Kd ratios flag unreliable data before it reaches your ELN.  When you’re satisfied, one click exports send all raw numbers, plots, and settings straight to Excel or a CSV file so colleagues can reproduce the calculation in third party tools.

With vendor neutral file import and parameter presets that match your lab’s protocol, Analytical Studio transforms AS MS binding studies from time sink to point and click.

Automated Kd Analysis in Affinity Selection-Mass Spectrometry

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May 15, 2025
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