Analytical Studio for Affinity Selection–Mass Spectrometry (AS-MS)
Purpose-built software for high-throughput AS-MS workflows, cross-hit filtering, and confident hit identification
Introduction
Affinity selection–mass spectrometry (AS-MS) workflows generate complex LC/MS datasets that traditional vendor software was not designed to process at screening scale. Analytical Studio combines full-plate cross-hit filtering, vendor-neutral LC/MS data processing, configurable scientific decision logic, and optional Kd analysis in a single workflow platform designed specifically for AS-MS.
From compound list import through curated hit list generation, Analytical Studio helps laboratories reduce false positives, accelerate screening campaigns, and improve confidence in downstream decisions.
End-to-End AS-MS Workflow Automation
Analytical Studio connects compound list import, LC/MS acquisition, cross-hit filtering, scientific review, and curated hit list generation within a single workflow environment.
Mixes of small molecules are incubated with a target compound, separated by chromatography, and analyzed by mass spec to identify compounds that non-covalently bind to the target
Features
Advanced Capabilities for High-Throughput AS-MS
Automated Workflow Infrastructure
Integrated sample management, automated sample list generation, and infrastructure-backed workflow automation streamline AS-MS processing from submission through review.
Scientific Decision Support
Automated full-plate cross-hit filtering, configurable expression-driven logic, and optional Kd analysis help laboratories generate higher-confidence hit lists with fewer false positives.
Performance & Scalability
Accelerated cross-hit filtering and scalable processing workflows support large AS-MS screening campaigns across multi-vendor laboratory environments.
Reduce False Positives with Cross-Hit Filtering
Not every detected compound represents a true binding event. In many AS-MS workflows, recurring background signals, carryover, isotopic interference, and isomeric compounds can appear as potential hits and advance into costly downstream assays.
Analytical Studio automates full-plate cross-hit filtering to systematically evaluate candidate hits across the entire experiment. Instead of manually extracting masses and reviewing surrounding wells, laboratories can automatically identify recurring signals using configurable criteria for mass confirmation, retention time matching, isotopic patterns, and peak thresholds.
By expanding analysis beyond limited-window review, Analytical Studio helps laboratories reduce false positives, accelerate review workflows, and generate higher-confidence hit lists.
In representative internal studies, expanding cross-hit analysis beyond nearby wells substantially increased recurring signal detection and reduced false-positive candidates before downstream follow-up
Scientific Decision Support
Analytical Studio combines chromatographic data, mass spectral data, metadata, and configurable scientific logic to support rapid and reproducible interpretation of AS-MS screening results.
Expression-driven workflows automate hit qualification, filtering criteria, review-by-exception workflows, and laboratory-specific decision logic while maintaining full transparency into how results are calculated and evaluated.
Interactive review tools enable analysts to compare references, bound/unbound samples, competitors, blanks, chromatograms, spectra, and compound-level results across the entire experiment for faster and more consistent hit confirmation.
Comparing low reference, high reference, no protein, and protein-containing control samples can further increase confidence in your results from Analytical Studio
Integrated Workflow Automation
Analytical Studio transforms fragmented AS-MS workflows into a connected, infrastructure-backed process spanning compound list import, automated sample list generation, LC/MS acquisition, centralized data processing, and curated hit list review.
Using Analytical Studio – Sample Management Services (AS-SMS) and Analytical Studio – Sample List Builder (AS-SLB), laboratories can automate metadata handling, instrument-ready sample list creation, and data transfer across multi-vendor environments.
The result is a scalable and reproducible workflow that reduces manual handling and improves traceability across screening campaigns.
Analytical Studio Informatics Solution: A fully-automated end-to-end solution for your high-throughput workflows
Optional Kd & Dose-Response Analysis
Analytical Studio offers optional Kd and dose-response curve analysis directly within the AS-MS workflow environment, enabling earlier affinity ranking and smarter hit prioritization during screening campaigns.
Automated curve fitting, quality metrics, and interactive visualization tools help laboratories evaluate binding behavior while maintaining traceability back to chromatographic and spectral evidence.
Structured export supports downstream pharmacology, reporting, and scientific informatics workflows.
Display your dose-response curve directly within Analytical Studio
Workflows in
Pharma/Biopharma
Virscidian Resources
The Stats
Our Impact by Numbers
80%
Of the top 10 Largest Pharma Companies in the world are customers
>50%
Of Fortune 500 Pharma companies are customers
Used by companies worldwide
Partner With Us
We partner with you to provide customized informatics solutions that use Analytical Studio to enhance decision making and accelerate your workflows.
