Affinity Selection-Mass Spectrometry: From Fundamentals to Confident Hit Identification
Turn complex AS-MS screening data into confident hit calls with practical tips on cross-hit filtering, false positives, and KD analysis
Affinity Selection-Mass Spectrometry, or AS-MS, is an increasingly valuable approach for identifying noncovalent binders in drug discovery screening workflows. In this webinar, Don Nguyen, PhD, Senior Scientist at Virscidian, explains the fundamentals of AS-MS, including how target proteins are screened against multiplexed compound libraries and how LC-MS enables direct detection of potential binders.
The session also explores one of the most challenging parts of AS-MS: turning complex, plate-scale screening data into confident, decision-ready hit calls. Don walks through common data review challenges, including compound compression, recurring background signals, false positives, and cross-hit filtering. The webinar also shows how Analytical Studio supports faster and more consistent AS-MS review through automated processing, linked navigation from wells and compounds to chromatograms, spectra, and metadata, and tools for KD analysis and hit confirmation.
This recording is especially relevant for analytical chemists, screening scientists, and drug discovery teams looking to improve AS-MS data review quality, turnaround time, and follow-up efficiency.
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